Loss and damage associated with the adverse effects of climate change is an urgent issue with impacts already being experienced by frontline communities. The establishment of the Santiago Network for Loss and Damage (SNLD) as part of the Warsaw International Mechanism for Loss and Damage associated with Climate Change Impacts(WIM) is a step in the right direction, but it needs to be fully operationalised. This policy brief from Practical Action looks at the lessons learned from the operationalisation of the Climate Technology Centre and Network (CTCN) and makes recommendations for the SNLD.